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Clark, D., Dedova, I., Cordwell, S., & Matsumoto, I. (2006). A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Mol Psychiatry, 11(5), 459–470.
Added by: J L (21 Jun 2007 15:17:24 UTC) Last edited by: J L (25 Jun 2007 10:24:10 UTC) |
| Resource type: Journal Article BibTeX citation key: Clark2006a Email resource to friend  |
Categories: General, Sciences Creators: Clark, Cordwell, Dedova, Matsumoto Collection: Mol Psychiatry |
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| Attachments | URLs http://www.mitrala ... rs-src/ACM2006.pdf |
| Abstract |
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The Anterior Cingulate Cortex (ACC, Brodmans Area 24) is implicated in the pathogenesis of schizophrenia due to its normal functions and connectivity together with reports of structural, morphological and neurotransmitter aberrations within this brain area in the disease state. Two-dimensional gel electrophoresis (2DE) was employed to scan and compare the ACC gray matter proteomes between schizophrenia (n = 10) and control (n = 10) post-mortem human tissue. This proteomic approach has detected 42 protein spots with altered levels in the schizophrenia cohort, which to our knowledge is the first proteomic analysis of the ACC in schizophrenia. Thirty nine of these proteins were subsequently identified using mass spectrometry and functionally classified into metabolism and oxidative stress, cytoskeletal, synaptic, signalling, trafficking and glial-specific groups. Some of the identified proteins have previously been implicated in the disease pathogenesis and some offer new insights into schizophrenia. Investigating these proteins, the genes encoding these proteins, their functions and interactions may shed light on the molecular mechanisms underlying the heterogeneous symptoms characteristic of schizophrenia.
Added by: J L Last edited by: J L |
| Notes |
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Department of Pathology, The University of Sydney, Sydney, NSW, Australia. Article on connectivity in anterior cingulate cortex gray matter Added by: J L Last edited by: J L |
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The Anterior Cingulate Cortex (ACC, Brodmans Area 24, BA24) is implicated in the pathogenesis of schizophrenia.
Added by: J L
Comments: nomenclature Added by: J L (2007-06-21 17:20:54) |
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Post-mortem examination has many possible confounding factors including PMI and pH. Cases were, therefore, matched for age, PMI and hemisphere to reduce these factors. Following post hoc statistical analysis, three proteins were found to have a positive correlation to either pH or PMI. The remaining 36 proteins altered in this study are most likely due to the disease. The possibility, however, that neuroleptics caused the alterations cannot be ruled out as all patients were medicated. As the neuroleptic dose was a wide range for most schizophrenia patients, Pearson correlations could not be performed. In addition, the effects of gender cannot be taken into consideration in this study as there were only two females in each group.
Added by: J L
Comments: confounding factors of experiment Added by: J L (2007-06-21 17:21:57) |
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Fresh frozen post-mortem human brain tissue from the gray matter of the ACC (BA24) of 10 nonpsychiatric controls and 10 schizophrenia individuals was obtained from the NSW Tissue Resource Centre (University of Sydney, NSW, Australia).
Added by: J L
Comments: Materials Added by: J L (2007-06-21 17:22:55) |
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(Bryce & Rutter, 2002, pp.10–11) Bryce, J., & Rutter, J. (2002). Spectacle of the deathmatch: Character and narrative in first-person shooters. In G. King & T. Krzywinska (Eds.), Screenplay: Cinema/Videogames/Interfaces (pp. 66–80). London: Wallflower Press. Added by: J L Comments: (King & Krzywinska, 2002) King, G., & Krzywinska, T. (2002). Cinema/videogames/interfaces. In G. King & T. Krzywinska (Eds.), Screenplay: Cinema/Videogames/Interfaces (pp. 1–32). London: Wallflower Press. Added by: J L (2007-06-22 13:03:42) |
| Musings |
| should be collated and included in molecular/neurotransmitter table Added by: J L (2007-06-21 17:24:04) |
| Great find! Added by: J L (2007-06-21 17:57:53) |
| I love this paper! Added by: J L (2007-06-22 10:14:59) |
| You are enjoying this aren't you ;) Added by: Mark Grimshaw (2007-06-22 13:05:00) |